- February 24 – 32nd Annual Spirit of Keokuk Awards
- March 25 – Downtown Quarterly Clean-Up
- May 6 – First Friday
- May 27 – 16th Annual Back Alley Bandfest
- June 3 – First Friday
- June 18 – Downtown Quarterly Clean-up
- July 1 – First Friday
- July 9 – 22nd Annual Summer Fun & Fundraiser
- July 21-23 65th Annual Crazy Days
- August 5 – First Friday
- September 2 – First Friday
- October 7 – First Friday
- October 22 – Downtown Quarterly Clean-Up
- October 28 – Downtown Trick or Treat
- November 4 – First Friday
- November 28 – Small Business Saturday
- December 2 – Puttin’ On the Glitz
- December 10 – Santa’s Workshop
If you have any questions about events happening in 2022, please call the MSKI office at (319)524-5056 or email director@mainstreetkeokuk.com